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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 62602Generated: October 26, 2026

Sodium Hydroxide → 3-Ethoxybicyclo[1.1.1]pentan-1-amine

https://huagongshe.com/reaction/62602

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium HydroxideHCID 14798—
ReactantN-{3-ethoxybicyclo[1.1.1]pentan-1-yl}acetamideHCID 86287954—
Product3-Ethoxybicyclo[1.1.1]pentan-1-amineHCID 86288025—

Reaction Steps

Hydrolysis of N-(3-ethoxybicyclo[1.1.1]pentan-1-yl)acetamide (2) with sodium hydroxide (or basic aqueous conditions) gives 3-ethoxybicyclo[1.1.1]pentan-1-amine (6) (Scheme 5).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09447025B2
Source datasetuspto-grants-2016_09
ORD IDord-312f84ba468849ce8adaf8e1d92ce761
Source noteuspto-grants-2016_09