反应详情

温度

120 °C

To a stirred solution of N-methoxy-N-methylthiophene-3-carboxamide (5.0 g, 1.0 eq, prepared from Example 12 step A) in 50 mL CH3COOH was added N-chlorosuccinimide (3.88 g, 1.0 eq). The mixture was then reflux at 120° C. for 4 h. After quenching with water, the mixture was extracted with ethyl acetate. The extract was washed with brine, dried, concentrated, and purified by column chromatography to get 3.0 g desired product (40% yield).

1. customAfter quenching with water
2. extractionthe mixture was extracted with ethyl acetate
3. washThe extract was washed with brine
4. customdried
5. concentrationconcentrated
6. custompurified by column chromatography