反应详情

To a solution of 3-fluoro-4-methoxybenzonitrile (350 mg, 2.32 mmol) in 15 mL anhydrous THF was added ethylmagnesium bromide (1 M in Et2O, 4.63 mL) at 0° C. The reaction mixture was stirred at rt overnight, then quenched with sat. NaHCO3, extracted with EtOAc, washed with brine, dried and evaporated. The residue was purified by column chromatography (eluent: petroleum ether/EtOAc=5/1) over silica gel to give the product (239 mg, 57% yield) as a yellow solid.

1. customquenched with sat. NaHCO3
2. extractionextracted with EtOAc
3. washwashed with brine
4. customdried
5. customevaporated
6. customThe residue was purified by column chromatography (eluent: petroleum ether/EtOAc=5/1) over silica gel