反应详情

1-(3-Fluoro-4-methoxyphenyl)propan-1-one (421 mg, 2.31 mmol) in 20 mL 40% HBr was refluxed for 1 h., neutralized with solid Na2CO3 at 0° C., and extracted with EtOAc. The extract was washed with brine, dried, concentrated, and purified by column chromatography (eluent: petroleum ether/EtOAc=5/1) over silica gel to give the product (257 mg, 66% yield) as a yellow solid.

1. extractionextracted with EtOAc
2. washThe extract was washed with brine
3. customdried
4. concentrationconcentrated
5. custompurified by column chromatography (eluent: petroleum ether/EtOAc=5/1) over silica gel