反应详情

To a suspension of 5-hydroxypicolinic acid (1.0 eq), HATU (1.2 eq) and N-methoxymethanamine hydrochloride (1.2 eq) in dry DMF was added DIEtOAc (2.5 eq) dropwise at rt. The mixture was then stirred overnight at rt. After addition with water, the mixture was extracted with CH2Cl2. The extract was dried, concentrated, and purified by column chromatography to give the desired product (87% yield).

1. additionwas added DIEtOAc (2.5 eq) dropwise at rt
2. extractionthe mixture was extracted with CH2Cl2
3. customThe extract was dried
4. concentrationconcentrated
5. custompurified by column chromatography