HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenyl-1-propanone → 6-(1-(4-(2-(Methylamino)ethoxy)phenyl)-2-phenylbut-1-enyl)pyridin-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenyl-1-propanone | HCID 7148 | — |
| Reactant | Tert-butyl 2-(4-(5-hydroxypicolinoyl)phenoxy)ethyl(methyl)carbamate | HCID 89656144 | — |
| Product | 6-(1-(4-(2-(Methylamino)ethoxy)phenyl)-2-phenylbut-1-enyl)pyridin-3-ol | HCID 78135504 | — |
Reaction Steps
Following general procedure of McMurry reaction as described in example 1, step B, tert-butyl 2-(4-(5-hydroxypicolinoyl)phenoxy)ethyl(methyl)carbamate (1.0 eq) was reacted with propiophenone (3.0 eq) to give the desired product (Z/E=1/1). m/z=375[M+1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09309211B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-d3b9bdc8fd074551981cad151c0f9b7c |
| Source note | uspto-grants-2016_04 |