反应详情

To a stirred solution of methyl 3-methyl-4-nitrobenzoate (50 g, 1.0 eq) in 1 L MeOH were added at rt a solution of NH4Cl (137 g, 10 eq) in 60 mL H2O and Fe power (96 g, 7 eq), and the resulting mixture is heated at reflux for 4 h. The reaction mixture was allowed to cool to rt, filtered, and water was added. The mixture was extracted with EtOAc. The extract was dried, washed with water, and concentrated to give the desired product directly as a white solid (26 g, 62%).

1. temperaturethe resulting mixture is heated
2. temperatureat reflux for 4 h
3. filtrationfiltered
4. additionwater was added
5. extractionThe mixture was extracted with EtOAc
6. customThe extract was dried
7. washwashed with water
8. concentrationconcentrated