反应详情

EtMgBr (1 M, 2.0 eq, 58 mL) was added to a solution of N-methoxy-N-methylbenzo[d]oxazole-5-carboxamide (6 g, 1.0 eq) in dry THF at 0° C., Once addition was complete, the mixture was stirred for 2 h. The reaction mixture was quenched with saturated NH4Cl and extracted with EtOAc. The extract was dried, concentrated, and purified by column chromatography with petroleum ether:EtOAc=1:1 to give the desired product (0.6 g, 12%)

1. additionOnce addition
2. customThe reaction mixture was quenched with saturated NH4Cl
3. extractionextracted with EtOAc
4. customThe extract was dried
5. concentrationconcentrated
6. custompurified by column chromatography with petroleum ether