反应详情

Bromination of (3) usinga brominating reagent such as bromine, N-bromosuccinimide, or phosphorous tribromide (as described in Elena Dvornikova et al., Synlett, 2002, No. 7, 1152-1154) yields 1-(3-bromo-5-(4-chlorophenyl)-1,4-dimethyl-1H-pyrrol-2-yl)-2-cyclopropylethanone (4). Preferably, the bromination reaction is carried out in the presence of N-bromosuccinimide in THF.