HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → HCID 121282944, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 1-(5-(4-chlorophenyl)-1,4-dimethyl-1H-pyrrol-2-yl)-2-cyclopropylethanone | HCID 117824093 | — |
| Product | HCID 121282944 | HCID 121282944 | — |
Reaction Steps
Bromination of (3) usinga brominating reagent such as bromine, N-bromosuccinimide, or phosphorous tribromide (as described in Elena Dvornikova et al., Synlett, 2002, No. 7, 1152-1154) yields 1-(3-bromo-5-(4-chlorophenyl)-1,4-dimethyl-1H-pyrrol-2-yl)-2-cyclopropylethanone (4). Preferably, the bromination reaction is carried out in the presence of N-bromosuccinimide in THF.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09447037B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-65cd14e2618b47ab885125172d1bad5d |
| Source note | uspto-grants-2016_09 |