HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenylpropan-1-amine → HCID 178457662, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenylpropan-1-amine | HCID 18054 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 5-Benzimidazolecarboxylic acid | HCID 459456 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178457662 | HCID 178457662 | — |
Reaction Steps
To a mixture of 5-benzimidazole-carboxylic acid in DMF was added DIPEA (1.3 equiv) and HATU (1.2 equiv). The mixture was stirred for 5 min, and then α-ethylbenzylamine (1.1 equiv) was added. The reaction mixture was stirred at rt. for 1 h. After the reaction was completed, the solvent was removed in vacuo to obtain the crude which was purified by flash chromatography to obtain the title compound. LC-MS 280 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09309227B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-361e8ee80b2f4d82aaeba12735cad980 |
| Source note | uspto-grants-2016_04 |