反应详情

To a mixture of 5-benzimidazole-carboxylic acid in DMF was added DIPEA (1.3 equiv) and HATU (1.2 equiv). The mixture was stirred for 5 min, and then α-ethylbenzylamine (1.1 equiv) was added. The reaction mixture was stirred at rt. for 1 h. After the reaction was completed, the solvent was removed in vacuo to obtain the crude which was purified by flash chromatography to obtain the title compound. LC-MS 280 (M+H).

1. stirringThe reaction mixture was stirred at rt
2. waitfor 1 h
3. customthe solvent was removed in vacuo
4. customto obtain the crude which
5. customwas purified by flash chromatography