HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 626395Generated: November 1, 2026
Water → (NE,S)-2-methyl-N-[1-(3-propan-2-ylphenyl)ethylidene]propane-2-sulfinamide
https://huagongshe.com/reaction/626395
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1-[3-(Propan-2-yl)phenyl]ethan-1-one | HCID 3085492 | — |
| Reactant | tert-Butylsulfinamide, (S)-(-)- | HCID 11355477 | — |
| Catalyst | HCID 178460666 | HCID 178460666 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (NE,S)-2-methyl-N-[1-(3-propan-2-ylphenyl)ethylidene]propane-2-sulfinamide | HCID 90373684 | — |
Reaction Steps
The mixture of 1-(3-isopropylphenyl)ethanone (5.8 g, 0.036 mol), (S)-2-methylpropane-2-sulfinamide (5.2 g, 0.043 mol) and Ti(OiPr)4 in THF was stirred at 90° C. for 16 hours. Then the mixture was poured to water and the solid was filtered, the filtrate was partitioned between EtOAc and water. The layers were separated and the organic layer was washed with water, brine, dried over Na2SO4, and concentrated. The residue was purified by column chromatography to give the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09309227B2 |
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| Source dataset | uspto-grants-2016_04 |
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| ORD ID | ord-4aec13a538694f578ad3705545c44689 |
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| Source note | uspto-grants-2016_04 |
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