(S)-N-((S)-1-(3-isopropylphenyl)ethyl)-2-methylpropane-2-sulfinamide → (S)-1-(3-isopropylphenyl)ethanamine

HRID 626397Notes

Reaction equation

HRID 626397 reaction equation
[CH:1]([C:4]1[CH:5]=[C:6]([C@@H:10]([NH:12][S@](C(C)(C)C)=O)[CH3:11])[CH:7]=[CH:8][CH:9]=1)([CH3:3])[CH3:2]>CO>[CH:1]([C:4]1[CH:5]=[C:6]([C@@H:10]([NH2:12])[CH3:11])[CH:7]=[CH:8][CH:9]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 86732637(S)-N-((S)-1-(3-isopropylphenyl)ethyl)-2-methylpropane-2-sulfinamide

Product 1

HCID 86674570(S)-1-(3-isopropylphenyl)ethanamine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The mixture of (S)—N—((S)-1-(3-isopropylphenyl)ethyl)-2-methylpropane-2-sulfinamide (6.1 g, 0.023 mol) in methanol was stirred at room temperature for 3 hours and then concentrated and evaporated with toluene for three times to give the titled compound which was without purification for next step.

Workup

  1. concentrationconcentrated
  2. customevaporated with toluene for three times

Sources & evidence

ORD record
ord-6aa35cfe6d984e308516c2debcf98c03
Source dataset
uspto-grants-2016_04
Patent number
US09309227B2

Reaction notes

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