Potassium Carbonate → HCID 24902937, compound

HRID 626402Notes

Reaction equation

F[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[Br:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][NH2:23])=[CH:18][CH:17]=1.C([O-])([O-])=O.[K+].[K+]>>[Br:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][NH:23][C:2]2[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=2[N+:12]([O-:14])=[O:13])=[CH:18][CH:17]=1

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 775714-Bromobenzylamine

HCID 5219721Methyl 4-fluoro-3-nitrobenzoate

Product 1

HCID 24902937HCID 24902937, compound

Conditions

Temperature: 40 °C

Procedure

The mixture of methyl 4-fluoro-3-nitrobenzoate (2 g, 10.1 mmol), (4-bromophenyl)methanamine (1.87 g, 10.1 mmol) and K2CO3 (2.77 g, 10.1 mmol) in TI-IF (40 mL) was stirred at 40° C. for 2 hrs, then the mixture was filtered and the filtrate was concentrated to get a yellow solid which was washed by MTBE and EtOAc (10/1,100 mL) to give the titled compound.

Workup

filtrationthe mixture was filtered
concentrationthe filtrate was concentrated
customto get a yellow solid which
washwas washed by MTBE and EtOAc (10/1,100 mL)

Sources & evidence

ORD record: ord-535dc988d7934d208cdac550749b2371
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09309227B2

Reaction notes

Loading…