rac-tert-Butyl 1-(3-{[cyclopent-1-en-1-yl(3,4-dihydroisoquinolin-2(1H)-yl)acetyl]amino}-4-fluorobenzyl)cyclopropanecarboxylate → rac-tert-Butyl 1-(3-{[cyclopentyl(3,4-dihydroisoquinolin-2(1H)-yl)acetyl]amino}-4-fluorobenzyl)cyclopropanecarboxylate

Participants

Reaction Steps

102 mg (0.2 mmol, purity 72%) of rac-tert-butyl 1-(3-{[cyclopent-1-en-1-yl(3,4-dihydroisoquinolin-2(1H)-yl)acetyl]amino}-4-fluorobenzyl)cyclopropanecarboxylate were initially charged in 14.4 ml of methanol, 14.4 mg (0.06 mmol) of platinum(IV) oxide were added and the mixture was hydrogenated at RT and standard pressure for 5 h. The mixture was then filtered through kieselguhr, the residue was washed thoroughly with methanol and the filtrate was concentrated under reduced pressure. This gave 102 mg (purity 36%) of the title compound which was reacted further without purification.

Provenance & Evidence