Ethyl 4-hydroxy-2-(methylsulfanyl)-5-pyrimidinecarboxylate → HCID 118159114, compound

HRID 626462Notes

Reaction equation

HRID 626462 reaction equation
CS[C:3]1[NH:4][C:5](=[O:14])[C:6]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:7][N:8]=1.[CH2:15]([N:22]1[CH2:26][CH2:25][CH:24]([NH2:27])[CH2:23]1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C(O)C>[CH2:15]([N:22]1[CH2:26][CH2:25][CH:24]([NH:27][C:3]2[NH:4][C:5](=[O:14])[C:6]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:7][N:8]=2)[CH2:23]1)[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 239049Ethyl 4-hydroxy-2-(methylsulfanyl)-5-pyrimidinecarboxylateHCID 27566131-Benzyl-3-aminopyrrolidine

Product 1

HCID 118159114HCID 118159114, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

Ethyl 2-(methylthio)-6-oxo-1,6-dihyropyrimidine-5-carboxylate (313 mg, 1.460 mmol) and 1-benzylpyrrolidin-3-amine (257 mg, 1.460 mmol) were dissolved in 10 mL of ethanol and heated at 80° C. overnight. The precipitate was not evident so the solution was heated to 90° C. overnight. The final product was then recovered.

Workup

  1. temperaturewas heated to 90° C. overnight
  2. customThe final product was then recovered

Sources & evidence

ORD record
ord-49bdf02b375f4de8a5259f7146f398ba
Source dataset
uspto-grants-2016_04
Patent number
US09309232B2

Reaction notes

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