Hydrochloric Acid → Ethyl 4-hydroxy-2-(methylsulfanyl)-5-pyrimidinecarboxylate

HRID 626466Notes

Reaction equation

HRID 626466 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7](=[O:14])[N-:8][C:9]([S:12][CH3:13])=[N:10][CH:11]=1)=[O:5])[CH3:2].C([Na])C.Cl>CO>[CH3:13][S:12][C:9]1[NH:8][C:7](=[O:14])[C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])=[CH:11][N:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178469863HCID 178469863, compound

Product 1

HCID 239049Ethyl 4-hydroxy-2-(methylsulfanyl)-5-pyrimidinecarboxylate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethyl sodium 5-(ethoxycarbonyl)-2-(methylthio)-4-oxo-4H-pyrimidin-3-ide (3.31 g, 14.00 mmol) was dissolved in 300 mL of methanol. 2 mL of HCl was added to the solution, which was condensed to yield the product.

Workup

  1. customcondensed
  2. customto yield the product

Sources & evidence

ORD record
ord-97c5bbe19fe048d3bd37d351f70c88fc
Source dataset
uspto-grants-2016_04
Patent number
US09309232B2

Reaction notes

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