Sodium Hydroxide → HCID 72192659, compound

HRID 626469Notes

Reaction equation

HRID 626469 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][C:10]([NH:13][C:14]3[NH:15][C:16](=[O:25])[C:17]([C:20]([O:22]CC)=[O:21])=[CH:18][N:19]=3)=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.[OH-].[Na+:27]>>[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][C:10]([NH:13][C:14]3[N:15]=[C:16]([O-:25])[C:17]([C:20]([O-:22])=[O:21])=[CH:18][N:19]=3)=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.[Na+:27].[Na+:27]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 72192371HCID 72192371, compound

Product 1

HCID 72192659HCID 72192659, compoundYield 132%

Conditions

Temperature
105 °C

Procedure

The mixture of ethyl 2-((4-morpholinophenyl)amino)-6-oxo-1,6-dihydropyrimidine-5-carboxylate (210 mg, 0.610 mmol) and sodium hydroxide (1M) were heated at 105° C. for 4 hours followed by heating at 40° C. overnight. Then the solution was condensed to recover the final product (290 mg, 132% yield). 1H-NMR confirmed the product.

Workup

  1. temperatureby heating at 40° C. overnight
  2. customcondensed

Sources & evidence

ORD record
ord-809d034bfb6c4d568b60fb2fee742cac
Source dataset
uspto-grants-2016_04
Patent number
US09309232B2

Reaction notes

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