HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl (4-((2-methyl-6-(3-pivaloylureido)pyridin-3-yl)oxy)pyridin-2-yl)carbamate → N-((5-((2-aminopyridin-4-yl)oxy)-6-methylpyridin-2-yl)carbamoyl)pivalamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl (4-((2-methyl-6-(3-pivaloylureido)pyridin-3-yl)oxy)pyridin-2-yl)carbamate | HCID 131735227 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | N-((5-((2-aminopyridin-4-yl)oxy)-6-methylpyridin-2-yl)carbamoyl)pivalamide | HCID 90410520 | 98% |
Reaction Steps
A mixture of tert-butyl (4-((2-methyl-6-(3-pivaloylureido)pyridin-3-yl)oxy)pyridin-2-yl)carbamate (0.370 g, 0.834 mmol in TFA (5 mL) was stirred at RT for 0.5 h and concentrated to dryness to afford N-((5-((2-aminopyridin-4-yl)oxy)-6-methylpyridin-2-yl)carbamoyl)pivalamide (280 mg, 98%). MS (ESI) m/z: 344.2 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09309224B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-3335abba83b643399b62ecb95fd29757 |
| Source note | uspto-grants-2016_04 |