反应详情

To a cooled (0° C.) solution of 4-azido-5-fluoro-pyridine-3-carbaldehyde (2.0 g, 12.0 mmol), 4-amino-3,5-dichlorobenzonitrile (2.25 g, 12.0 mmol) and triethylamine (5.0 mL, 36.1 mmol) in DCM (48 mL) was added titanium tetrachloride (1M in DCM, 7.2 mL, 7.2 mmol) dropwise over 20 minutes. The reaction mixture was stirred for 20 minutes, warmed to room temperature, and stirred for a further 30 minutes. The resultant mixture was concentrated to dryness under reduced pressure to afford the title compound, which was used without further purification.

1. stirringstirred for a further 30 minutes
2. concentrationThe resultant mixture was concentrated to dryness under reduced pressure