反应详情

温度

150 °C

A mixture of 2-(4-bromo-7-fluoropyrazolo[4,3-c]pyridin-2-yl)-3-chlorobenzonitrile (158 mg, 0.45 mmol), 4-amino-6-methylpyrimidine (55 mg, 0.5 mmol), Pd2(dba)3 (10 mg, 0.011 mmol), Xantphos (26 mg, 0.045 mmol) and cesium carbonate (293 mg, 0.9 mmol) in dioxane (3 mL) was de-gassed and purged with nitrogen and the reaction mixture was heated at 150° C. in the microwave for 30 minutes. The resultant mixture was partitioned between ethyl acetate and water. The layers were separated and the organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel flash chromatography (80-90% ethyl acetate in cyclohexane) to afford the title compound as a beige solid (81 mg, 47% yield). 1H NMR (400 MHz, DMSO-d6): δ 10.83 (s, 1H), 9.48 (d, J=2.6 Hz, 1H), 8.71 (d, J=1.2 Hz, 1H), 8.38 (s, 1H), 8.23-8.20 (m, 2H), 8.03 (d, J=3.5 Hz, 1H), 7.92 (t, J=8.1 Hz, 1H), 2.46 (s, 3H). LCMS (Method B): RT=3.04 min, m/z: 380 [M+H+].

1. customwas de-gassed
2. custompurged with nitrogen
3. customThe resultant mixture was partitioned between ethyl acetate and water
4. customThe layers were separated
5. washthe organic layer was washed with brine
6. dry with materialdried over anhydrous sodium sulfate
7. filtrationfiltered
8. concentrationconcentrated under reduced pressure
9. customThe residue was purified by silica gel flash chromatography (80-90% ethyl acetate in cyclohexane)