反应详情

To a solution of methyl 7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylate (300 mg, 1.55 mmol) in dry DMF (5 mL) K2CO3 (429 mg, 3.10 mmol) and methyl iodide (0.193 mL, 3.10 mmol) were added. The reaction was stirred at room temperature for 3 h, then H2O was added (100 mL) and the product extracted with DCM (3×30 mL). The organic fractions were dried over Na2SO4, filtered, and concentrated in vacuo to give 305 mg (yield: 95%) as light yellow solid.

1. extractionthe product extracted with DCM (3×30 mL)
2. dry with materialThe organic fractions were dried over Na2SO4
3. filtrationfiltered
4. concentrationconcentrated in vacuo
5. customto give 305 mg (yield: 95%) as light yellow solid