(2-Chloropyrimidin-5-yl)boronic acid → {2-[4-(Methylsulfonyl)piperidin-1-yl]pyrimidin-5-yl}boronic acid

HRID 626969Notes

Reaction equation

HRID 626969 reaction equation
[CH3:1][S:2]([CH:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)(=[O:4])=[O:3].Cl[C:12]1[N:17]=[CH:16][C:15]([B:18]([OH:20])[OH:19])=[CH:14][N:13]=1>>[CH3:1][S:2]([CH:5]1[CH2:10][CH2:9][N:8]([C:12]2[N:17]=[CH:16][C:15]([B:18]([OH:20])[OH:19])=[CH:14][N:13]=2)[CH2:7][CH2:6]1)(=[O:4])=[O:3]

Participants

3

Reactant 2

HCID 21747362(2-Chloropyrimidin-5-yl)boronic acidHCID 222750384-(Methanesulfonyl)piperidine

Product 1

HCID 131735244{2-[4-(Methylsulfonyl)piperidin-1-yl]pyrimidin-5-yl}boronic acid

Procedure

Prepared from 4-(methylsulfonyl)piperidine (0.515 g, 3.16 mmol) and (2-chloropyrimidin-5-yl)boronic acid (0.5 g, 3.16 mmol) in accordance with General Method C to give the title compound as an off-white semi-solid. HPLC-MS: m/z MH+ 286.2, RT 0.17 minutes.

Sources & evidence

ORD record
ord-f3674d9d3b4c4a319438e6d541bf6878
Source dataset
uspto-grants-2016_04
Patent number
US09309243B2

Reaction notes

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