(-)-Nipecotic acid → (3R)-1-(5-Boronopyrimidin-2-yl)piperidine-3-carboxylic acid

HRID 626971Notes

Reaction equation

HRID 626971 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([B:8]([OH:10])[OH:9])=[CH:4][N:3]=1.[NH:11]1[CH2:16][CH2:15][CH2:14][C@@H:13]([C:17]([OH:19])=[O:18])[CH2:12]1>>[B:8]([C:5]1[CH:4]=[N:3][C:2]([N:11]2[CH2:16][CH2:15][CH2:14][C@@H:13]([C:17]([OH:19])=[O:18])[CH2:12]2)=[N:7][CH:6]=1)([OH:10])[OH:9]

Participants

3

Reactant 2

HCID 1796510(-)-Nipecotic acidHCID 21747362(2-Chloropyrimidin-5-yl)boronic acid

Product 1

HCID 119087137(3R)-1-(5-Boronopyrimidin-2-yl)piperidine-3-carboxylic acid

Procedure

The title compound was synthesised from (2-chloropyrimidin-5-yl)boronic acid and (3R)-piperidine-3-carboxylic acid in accordance with General Method C.

Sources & evidence

ORD record
ord-a2c806682e7342b5a8e57826d7de2b80
Source dataset
uspto-grants-2016_04
Patent number
US09309243B2

Reaction notes

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