反应详情

In a 100 mL round-bottomed flask, tert-butyl 2-(ethylcarbamoyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-1-carboxylate (402 mg, 1.38 mmol, Eq: 1.00) was combined with DCM (8 mL) to give a colorless solution. TFA (2 mL, 26.0 mmol, Eq: 18.8) was added and the reaction was stirred at rt for 6 h. The reaction mixture was concentrated in vacuo, saturated aqueous NaHCO3 (30 mL) was added and the resulting mixture was extracted with DCM (20 mL×3). The organic layers were dried over Na2SO4 and concentrated in vacuo to give 2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethylamide as an off-white solid (210 mg), m/z=192 (M+H).

1. customto give a colorless solution
2. concentrationThe reaction mixture was concentrated in vacuo, saturated aqueous NaHCO3 (30 mL)
3. additionwas added
4. extractionthe resulting mixture was extracted with DCM (20 mL×3)
5. dry with materialThe organic layers were dried over Na2SO4
6. concentrationconcentrated in vacuo