Propargylamine → HCID 86707259, compound

HRID 627317Notes

Reaction equation

HRID 627317 reaction equation
[S:1]1[CH2:5][CH2:4][C@H:3]([CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=O)[S:2]1.[CH2:13]([NH2:16])[C:14]#[CH:15]>>[S:1]1[CH2:5][CH2:4][C@H:3]([CH2:6][CH2:7][CH2:8][CH2:9][C:10]([NH:16][CH2:13][C:14]#[CH:15])=[O:12])[S:2]1

Participants

3

Reactant 2

HCID 239041PropargylamineHCID 445125(S)-Lipoic acid

Product 1

HCID 86707259HCID 86707259, compound

Procedure

In amide coupling reaction (as shown in Scheme 10), (S)-5-(1,2-dithiolan-3-yl)pentanoic acid (11) and prop-2-yn-1-amine perform coupling reaction to form (S)-5-(1,2-dithiolan-3-yl)-N-(prop-2-ynyl)pentanamide (12).

Workup

  1. customreaction

Sources & evidence

ORD record
ord-6f570fc2c70941839cce331a9d8e0813
Source dataset
uspto-grants-2016_04
Patent number
US09309268B2

Reaction notes

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