Methyl 3-chloro-5-isopropoxy-4-methoxybenzoate → 3-Chloro-5-isopropoxy-4-methoxybenzoic acid

HRID 62746Notes

Reaction equation

HRID 62746 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([O:14][CH:15]([CH3:17])[CH3:16])[C:11]=1[O:12][CH3:13])[C:5]([O:7]C)=[O:6]>CO>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([O:14][CH:15]([CH3:17])[CH3:16])[C:11]=1[O:12][CH3:13])[C:5]([OH:7])=[O:6]

Participants

3

Reactant 1

HCID 67041761Methyl 3-chloro-5-isopropoxy-4-methoxybenzoate

Product 1

HCID 670417623-Chloro-5-isopropoxy-4-methoxybenzoic acidYield 92.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3-Chloro-5-isopropoxy-4-methoxybenzoic acid (5) (0.93 g, 89%) was prepared from methyl 3-chloro-5-isopropoxy-4-methoxybenzoate (4) (1.06 g, 4.10 mmol) using a procedure essentially the same as in step (ii) for AAA-001 except that MeOH instead of water was added dropwise until a solution formed: m/z 243 [M−H]− (ES−).

Workup

  1. additionwas added dropwise until a solution
  2. customformed

Sources & evidence

ORD record
ord-d4216ef25f214b4daa51ead535c05bab
Source dataset
uspto-grants-2016_09
Patent number
US09447028B2

Reaction notes

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