HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 627490Generated: October 27, 2026
Thionyl Chloride → 2-Fluoropyridine-5-carbonyl chloride
https://huagongshe.com/reaction/627490
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 6-Fluoronicotinic Acid | HCID 242819 | — |
| Product | 2-Fluoropyridine-5-carbonyl chloride | HCID 14623602 | — |
Reaction Steps
In a 100-mL round-bottom flask was placed a solution of 6-fluoropyridine-3-carboxylic acid (5.0 g, 35.4 mmol) in thionyl chloride (20 mL). The resulting solution was heated at 80° C. for 2 hours and concentrated under vacuum to give the title compound as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09309222B2 |
|---|
| Source dataset | uspto-grants-2016_04 |
|---|
| ORD ID | ord-7ebacbd88c974eeaa7baa374f072bab9 |
|---|
| Source note | uspto-grants-2016_04 |
|---|
