反应详情

温度

110 °C

A mixture of 6-bromo-2,4-dichloro-8-methyl-3-(4-(trifluoromethoxy)phenyl)quinoline (1.97 g, 4.367 mmol, Intermediate 58, step c) and sodium methoxide (1.18 g, 21.837 mmol) in toluene (20 mL) was heated in a sealed tube at 110° C. for 24 hours, cooled to RT, diluted with DCM, stirred at room temperature for 30 min, and filtered through Celite® rinsing several times with DCM. The solvents were removed under reduced pressure and the off-white solid product precipitated from MeOH, filtered and dried to provide the title compound.

1. temperaturecooled to RT
2. filtrationfiltered through Celite®
3. washrinsing several times with DCM
4. customThe solvents were removed under reduced pressure
5. customthe off-white solid product precipitated from MeOH
6. filtrationfiltered
7. customdried