Sodium Methoxide → 6-Bromo-4-chloro-2-methoxy-8-methyl-3-(4-(trifluoromethoxy)phenyl)quinoline

HRID 627538ノート

反応式

HRID 627538 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH3:12])[CH:11]=1)[N:8]=[C:7](Cl)[C:6]([C:14]1[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=1)=[C:5]2[Cl:25].[CH3:26][O-:27].[Na+]>C1(C)C=CC=CC=1.C(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH3:12])[CH:11]=1)[N:8]=[C:7]([O:27][CH3:26])[C:6]([C:14]1[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=1)=[C:5]2[Cl:25]

参加物

5

反応物 2

HCID 10942334Sodium MethoxideHCID 867161016-Bromo-2,4-dichloro-8-methyl-3-(4-(trifluoromethoxy)phenyl)quinoline2 回

生成物 1

HCID 867161006-Bromo-4-chloro-2-methoxy-8-methyl-3-(4-(trifluoromethoxy)phenyl)quinoline

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 6344Dichloromethane溶媒

反応条件

温度
110 °C

実験手順

A mixture of 6-bromo-2,4-dichloro-8-methyl-3-(4-(trifluoromethoxy)phenyl)quinoline (1.97 g, 4.367 mmol, Intermediate 58, step c) and sodium methoxide (1.18 g, 21.837 mmol) in toluene (20 mL) was heated in a sealed tube at 110° C. for 24 hours, cooled to RT, diluted with DCM, stirred at room temperature for 30 min, and filtered through Celite® rinsing several times with DCM. The solvents were removed under reduced pressure and the off-white solid product precipitated from MeOH, filtered and dried to provide the title compound.

後処理

  1. temperaturecooled to RT
  2. filtrationfiltered through Celite®
  3. washrinsing several times with DCM
  4. customThe solvents were removed under reduced pressure
  5. customthe off-white solid product precipitated from MeOH
  6. filtrationfiltered
  7. customdried

出典と根拠

ORDレコード
ord-d5ee121f8f854c18a885cfbf8d7a39ba
出典データセット
uspto-grants-2016_04
特許番号
US09309222B2

反応ノート

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