Sodium Methoxide → 6-Bromo-4-chloro-2-methoxy-8-methyl-3-(4-(trifluoromethoxy)phenyl)quinoline

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-bromo-2,4-dichloro-8-methyl-3-(4-(trifluoromethoxy)phenyl)quinoline (1.97 g, 4.367 mmol, Intermediate 58, step c) and sodium methoxide (1.18 g, 21.837 mmol) in toluene (20 mL) was heated in a sealed tube at 110° C. for 24 hours, cooled to RT, diluted with DCM, stirred at room temperature for 30 min, and filtered through Celite® rinsing several times with DCM. The solvents were removed under reduced pressure and the off-white solid product precipitated from MeOH, filtered and dried to provide the title compound.

Provenance & Evidence