反应详情

温度

50 °C

A mixture of diethyl 2-(4-fluorophenyl)malonate (2.98 g, 8.204 mmol, Intermediate 59, step a) and an aqueous 3 M NaOH solution (5 mL) were stirred in a 50° C. oil bath for 48 hours, cooled to RT, poured into ice water and acidified with 6N HCl. The aqueous mixture was extracted with EtOAc. The EtOAc extract was dried over Na2SO4, filtered, and evaporated in vacuo to provide the title compound.

1. temperaturecooled to RT
2. extractionThe aqueous mixture was extracted with EtOAc
3. extractionThe EtOAc extract
4. dry with materialwas dried over Na2SO4
5. filtrationfiltered
6. customevaporated in vacuo