HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Chlorophenyl)(pyridin-3-yl)methanone → (4-Chloro-3-phenylquinolin-6-yl)(3-methoxyphenyl)pyridin-3-ylmethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Chlorophenyl)(pyridin-3-yl)methanone | HCID 2748413 | — |
| Reactant | 3-(3-Methoxybenzoyl)pyridine | HCID 10036137 | — |
| Reactant | 6-Bromo-4-hydroxy-3-phenylquinolin-2(1H)-one | HCID 86716056 | — |
| Product | (4-Chloro-3-phenylquinolin-6-yl)(3-methoxyphenyl)pyridin-3-ylmethanol | HCID 74222051 | — |
Reaction Steps
The title compound was prepared using 6-bromo-4-chloro-3-phenylquinoline (Intermediate 3, step c) and (3-methoxyphenyl)(pyridin-3-yl)methanone in place of 6-bromo-2,4-dichloro-3-phenylquinoline and (3-chlorophenyl)(pyridin-3-yl)methanone, respectively, according to the procedure described in Example 25. 1H NMR (400 MHz, CDCl3) δ 8.83 (s, 1H), 8.61-8.65 (m, 1H), 8.53-8.57 (m, 1H), 8.37 (d, J=1.96 Hz, 1H), 8.09 (d, J=9.05 Hz, 1H), 7.68-7.75 (m, 2H), 7.50-7.55 (m, 5H), 7.26-7.30 (m, 2H), 6.83-6.91 (m, 3H), 3.75 (s, 3H); MS m/e 452.9 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09309222B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-940dbf7458b14db1931da32de5ab296f |
| Source note | uspto-grants-2016_04 |