HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Chlorophenyl)(pyridin-3-yl)methanone → (4-Chloro-3-phenylquinolin-6-yl)(6-chloropyridin-3-yl)(3-fluorophenyl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Chlorophenyl)(pyridin-3-yl)methanone | HCID 2748413 | — |
| Reactant | 2-Chloro-5-(3-fluorobenzoyl)pyridine | HCID 49762694 | — |
| Reactant | 6-Bromo-4-hydroxy-3-phenylquinolin-2(1H)-one | HCID 86716056 | — |
| Product | (4-Chloro-3-phenylquinolin-6-yl)(6-chloropyridin-3-yl)(3-fluorophenyl)methanol | HCID 74222220 | — |
Reaction Steps
The title compound was prepared using 6-bromo-4-chloro-3-phenylquinoline (Intermediate 3, step c) and (3-fluorophenyl)(6-chloropyridin-3-yl)methanone in place of 6-bromo-2,4-dichloro-3-phenylquinoline and (3-chlorophenyl)(pyridin-3-yl)methanone, respectively, according to the procedure described in Example 25. 1H NMR (400 MHz, CDCl3) δ 8.81 (s, 1H), 8.40 (d, J=2.69 Hz, 1H), 8.30 (d, J=2.20 Hz, 1H), 8.10 (d, J=8.80 Hz, 1H), 7.68 (ddd, J=2.20, 8.62, 17.55 Hz, 2H), 7.46-7.54 (m, 5H), 7.33 (d, J=8.56 Hz, 2H), 7.05-7.11 (m, 3H); MS m/e 474.9 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09309222B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-9274f4ecb7804b2381dc6332aafea067 |
| Source note | uspto-grants-2016_04 |