Tert-butyl 4-benzoylpiperidine-1-carboxylate → HCID 86716138, compound

HRID 627563Notes

Reaction equation

HRID 627563 reaction equation
C(C1CCN([C:15]([O:17]C(C)(C)C)=[O:16])CC1)(=O)C1C=CC=CC=1.[OH:22][C:23]([C:61]1[CH:66]=[CH:65][CH:64]=[CH:63][CH:62]=1)([C:37]1[CH:38]=[C:39]2[C:44](=[CH:45][CH:46]=1)[N:43]=[C:42]([C:47]([F:50])([F:49])[F:48])[C:41]([C:51]1[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=1)=[C:40]2[C:57]([F:60])([F:59])[F:58])[CH:24]1[CH2:29][CH2:28][N:27](C(OC(C)(C)C)=O)[CH2:26][CH2:25]1>>[C:61]1([C:23]([C:37]2[CH:38]=[C:39]3[C:44](=[CH:45][CH:46]=2)[N:43]=[C:42]([C:47]([F:48])([F:49])[F:50])[C:41]([C:51]2[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=2)=[C:40]3[C:57]([F:59])([F:60])[F:58])([CH:24]2[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]2)[OH:22])[CH:66]=[CH:65][CH:64]=[CH:63][CH:62]=1.[C:15]([OH:17])([C:47]([F:50])([F:49])[F:48])=[O:16]

Participants

3

Reactant 2

HCID 10827307Tert-butyl 4-benzoylpiperidine-1-carboxylateHCID 86716140HCID 86716140, compound

Product 1

HCID 86716138HCID 86716138, compound

Procedure

The precursor of the title compound was prepared essentially as described for Example 164, using tert-butyl 4-benzoylpiperidine-1-carboxylate (commercial; e.g., Matrix Scientific) in place of (1-methyl-1H-imidazol-5-yl)(pyridin-4-yl)methanone to provide, after heptanes/acetone flash chromatography, tert-butyl 4-(hydroxy(phenyl)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)piperidine-1-carboxylate as a clear yellow oil.

Workup

  1. customto provide

Sources & evidence

ORD record
ord-1023576565b64ba8845e8cb4318e1cf3
Source dataset
uspto-grants-2016_04
Patent number
US09309222B2

Reaction notes

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