反应详情

A solution of compound 1 (10.55 g: 31 mmol) in DCM (100 mL) was treated with 4M HCl in dioxane (78 mL; 0.31 mol) and stirred at room temperature for 3 h while monitoring the disappearance of the starting material by TLC. The solvent was removed on the rotary evaporator and the residue was treated with ether and then concentrated to give 2 as an off white solid (8.3 g; 96% yield).

1. customThe solvent was removed on the rotary evaporator
2. additionthe residue was treated with ether
3. concentrationconcentrated
4. customto give 2 as an off white solid (8.3 g; 96% yield)