Hydrogen chloride-ethyl acetate → (S)-2-aMino-N,N-diMethylpropanaMide HCl

Participants

Reaction Steps

To a solution of Boc-L-alanine N,N-dimethyl amide (250 mg, 1.1 mmol) in EtOAc (1 mL) was added HCl/EtOAc (4M, 3 mL) at 0° C. The solution was kept at room temperature for 30 min, and then concentrated under reduced pressure to give L-alanine N,N-dimethyl amide hydrochloride as a white solid (176 mg, 100%).

Provenance & Evidence