Hydrogen chloride-ethyl acetate → (S)-2-aMino-N,N-diMethylpropanaMide HCl

HRID 627587Notes

Reaction equation

HRID 627587 reaction equation
[CH3:1][N:2]([CH3:15])[C:3](=[O:14])[C@H:4]([CH3:13])[NH:5]C(OC(C)(C)C)=O.[ClH:16].CCOC(C)=O>CCOC(C)=O>[ClH:16].[CH3:1][N:2]([CH3:15])[C:3](=[O:14])[C@H:4]([CH3:13])[NH2:5]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 28165235HCID 28165235, compound

Product 1

HCID 57517873(S)-2-aMino-N,N-diMethylpropanaMide HClYield 100%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of Boc-L-alanine N,N-dimethyl amide (250 mg, 1.1 mmol) in EtOAc (1 mL) was added HCl/EtOAc (4M, 3 mL) at 0° C. The solution was kept at room temperature for 30 min, and then concentrated under reduced pressure to give L-alanine N,N-dimethyl amide hydrochloride as a white solid (176 mg, 100%).

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-3d9f6a9142804326877ba0ee96ac8983
Source dataset
uspto-grants-2016_04
Patent number
US09309285B2

Reaction notes

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