Hydrochloride methanol → HCID 131735323, compound

HRID 627591Notes

Reaction equation

HRID 627591 reaction equation
[NH:1]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[C@H:2]([C:9]([OH:11])=[O:10])[CH2:3][CH2:4][O:5][CH2:6][CH:7]=[CH2:8].[ClH:19].[CH3:20]O>>[NH:1]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[C@H:2]([C:9]([O:11][CH3:20])=[O:10])[CH2:3][CH2:4][O:5][CH2:6][CH:7]=[CH2:8].[ClH:19]

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 58798660N-Boc-O-allyl-L-homoserine

Product 1

HCID 131735323HCID 131735323, compoundYield 98.9%

Procedure

A solution of Boc-L-HomoSer(O-allyl)-OH (4.50 g, 17.4 mmol) in HCl/MeOH (50 mL) was stirred at 20° C. for 6 hrs. The solvent was removed at reduced pressure to give Boc-L-HomoSer(allyl)-OMe HCl (3.60 g, 98.9%).

Workup

  1. customThe solvent was removed at reduced pressure

Sources & evidence

ORD record
ord-26416241fef946b4853cd7d92f9d5d07
Source dataset
uspto-grants-2016_04
Patent number
US09309285B2

Reaction notes

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