2-Bromopropane → HCID 67041582, compound

HRID 62768Notes

Reaction equation

[Cl:1][C:2]1[C:10]([OH:11])=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[OH:12].[CH:13](Br)([CH3:15])[CH3:14]>>[Cl:1][C:2]1[C:10]([O:11][CH:2]([CH3:10])[CH3:3])=[CH:9][C:5]([C:6]([O:8][CH:13]([CH3:15])[CH3:14])=[O:7])=[CH:4][C:3]=1[O:12][CH:5]([CH3:6])[CH3:4]

Participants

Reactant 2

HCID 63582-Bromopropane

HCID 3025235alpha-Resorcylic acid, 4-chloro-

Product 1

HCID 67041582HCID 67041582, compound

Conditions

Temperature: 50 °C

Procedure

Isopropyl 4-chloro-3,5-diisopropoxybenzoate (4) (43 mg, 0.12 mmol) was prepared from 4-chloro-3,5-dihydroxybenzoic acid (3) (72 mg, 0.38 mmol) using a procedure essentially the same as in step (i) for AAA-001 except that isopropyl bromide (8 eq.) was used instead of cyclopentyl bromide and the mixture was stirred at 50° C. for 20 h: 1H NMR (400 MHz, CDCl3) δ: 7.25 (2H, s), 5.23 (1H, sep), 4.63 (2H, sep), 1.38 (18H, m).

Sources & evidence

ORD record: ord-4d19b0a9d1414244a43cb2b6b6ca5fe5
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09447028B2

Reaction notes

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