Hydrochloric Acid → 5-(2,2,2-Trifluoroethoxy)pyrazine-2-carboxylic acid

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	Methyl 5-(2,2,2-trifluoroethoxy)pyrazine-2-carboxylate	HCID 57827340	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	5-(2,2,2-Trifluoroethoxy)pyrazine-2-carboxylic acid	HCID 57827692	—

Reaction Conditions

Temperature	80 °C

Reaction Steps

To a mixture of methyl 5-(2,2,2-trifluoroethoxy)pyrazine-2-carboxylate (200 mg, 0.847 mmol) in Dioxane (1.2 mL) was added aqueous 2N HCl (1.0 mL). The reaction was stirred at 80° C. for 16 hrs. The reaction was concentrated in vacuo to afford the title compound quantitatively (188 mg, 0.847 mmol). MS m/z=223.1 (M+H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09309263B2
Source dataset	uspto-grants-2016_04
ORD ID	ord-cb82e3e27d504c95ab135ef7d6f44fef
Source note	uspto-grants-2016_04