Hydrochloric Acid → 5-(2,2,2-Trifluoroethoxy)pyrazine-2-carboxylic acid

HRID 627726Notes

Reaction equation

[F:1][C:2]([F:16])([F:15])[CH2:3][O:4][C:5]1[N:6]=[CH:7][C:8]([C:11]([O:13]C)=[O:12])=[N:9][CH:10]=1.Cl>O1CCOCC1>[F:16][C:2]([F:1])([F:15])[CH2:3][O:4][C:5]1[N:6]=[CH:7][C:8]([C:11]([OH:13])=[O:12])=[N:9][CH:10]=1

Participants

Conditions

Temperature: 80 °C

Procedure

To a mixture of methyl 5-(2,2,2-trifluoroethoxy)pyrazine-2-carboxylate (200 mg, 0.847 mmol) in Dioxane (1.2 mL) was added aqueous 2N HCl (1.0 mL). The reaction was stirred at 80° C. for 16 hrs. The reaction was concentrated in vacuo to afford the title compound quantitatively (188 mg, 0.847 mmol). MS m/z=223.1 (M+H).

Workup

concentrationThe reaction was concentrated in vacuo

Sources & evidence

ORD record: ord-cb82e3e27d504c95ab135ef7d6f44fef
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09309263B2

Reaction notes

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