2,4-difluoro-N-methylaniline → N-(2,4-difluorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide

HRID 627886Notes

Reaction equation

HRID 627886 reaction equation
[S:1]1[C:5]2[C:6]3[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=3[O:8][CH2:9][CH2:10][C:4]=2[CH:3]=[C:2]1[C:15]([OH:17])=O.[F:18][C:19]1[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:20]=1[NH:21][CH3:22]>>[F:18][C:19]1[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:20]=1[N:21]([CH3:22])[C:15]([C:2]1[S:1][C:5]2[C:6]3[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=3[O:8][CH2:9][CH2:10][C:4]=2[CH:3]=1)=[O:17]

Participants

3

Reactant 2

HCID 27370232,4-difluoro-N-methylanilineHCID 568340534,5-Dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxylic acid

Product 1

HCID 44242493N-(2,4-difluorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide

Procedure

Following General Procedure C, 156 is prepared from 4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxylic acid and 2,4-difluoro-N-methylaniline. MS: (ESI+) 371.9

Sources & evidence

ORD record
ord-395df252b6904ca999742bf9a7e82966
Source dataset
uspto-grants-2016_04
Patent number
US09309265B2

Reaction notes

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