反应详情

2-[4-(2,4-Difluoro-phenyl)-4H-[1,2,4]triazol-3-yl]-4,5-dihydro-6-oxa-1-thia-benzo[e]azulene-9-carboxylic acid and N-methylpiperazine were reacted in the general amide coupling procedure to give 374. NMR: (CDCl3): 2.37 (3H, s, Me), 2.37-2.51 (4H, m), 3.13-3.17 (2H, m), 3.51-3.78 (4H, m), 4.32-4.35 (2H, m), 6.98 (1H, s, Ar), 7.05 (1H, d, J 8.3, Ar), 7.12-7.17 (2H, m, Ar), 7.24-7.27 (1H, m, Ar), 7.42-7.48 (1H, m, Ar), 7.61-7.62 (1H, m, Ar) and 8.24 (1H, s, Ar). MS: (ESI+) MH+=508.22