Tert-butyl 3-(benzylamino)benzoate → HCID 3681313, compound

HRID 62820Notes

Reaction equation

HRID 62820 reaction equation
C([O:5][C:6](=[O:21])[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([NH:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:8]=1)(C)(C)C>FC(F)(F)C(O)=O.ClCCl>[CH2:14]([NH:13][C:9]1[CH:8]=[C:7]([CH:12]=[CH:11][CH:10]=1)[C:6]([OH:21])=[O:5])[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 1

HCID 24973583Tert-butyl 3-(benzylamino)benzoate

Product 1

HCID 3681313HCID 3681313, compound

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

A solution of 3-benzylamino-benzoic acid tert-butyl ester (1 g, 3 mmol) in trifluoroacetic acid/dichloromethane (1:5 v/v) (100 ml) was stirred for 16 hrs. The reaction was concentrated to dryness in vacuo to afford the title compound as a white solid. HPLC retention time 2.59 min. Mass spectrum (ES+) m/z 227.8 (M+).

Workup

  1. concentrationThe reaction was concentrated to dryness in vacuo

Sources & evidence

ORD record
ord-4bc2eb90970346a891c68c1f5cbee983
Source dataset
uspto-grants-2016_09
Patent number
US09447033B2

Reaction notes

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