Pyrrolidine → HCID 118159595, compound

HRID 628282Notes

Reaction equation

HRID 628282 reaction equation
[CH3:1][C:2]1[N:6]2[C:7]3[CH:13]=[C:12]([CH3:14])[N:11]([CH2:15][C:16]4[CH:21]=[CH:20][C:19]([CH2:22]O)=[CH:18][CH:17]=4)[C:8]=3[CH:9]=[CH:10][C:5]2=[N:4][N:3]=1.[NH:24]1[CH2:28][CH2:27][CH2:26][CH2:25]1>>[CH3:1][C:2]1[N:6]2[C:7]3[CH:13]=[C:12]([CH3:14])[N:11]([CH2:15][C:16]4[CH:21]=[CH:20][C:19]([CH2:22][N:24]5[CH2:28][CH2:27][CH2:26][CH2:25]5)=[CH:18][CH:17]=4)[C:8]=3[CH:9]=[CH:10][C:5]2=[N:4][N:3]=1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 118159705HCID 118159705, compound

Product 1

HCID 118159595HCID 118159595, compound

Procedure

The title compound was prepared according to the procedures of Example 45, using the alcohol of Example 49 as starting material and using pyrrolidine (0.016 mL, 0.20 mmol, Aldrich) in the displacement, which was performed overnight (11.2 mg, 64%).

Sources & evidence

ORD record
ord-ed558060713e4b68a11934e4b8d070ba
Source dataset
uspto-grants-2016_04
Patent number
US09309246B2

Reaction notes

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