Diisopropylethylamine → HCID 118159814, compound

HRID 628283Notes

Reaction equation

HRID 628283 reaction equation
[CH3:1][C:2]1[N:6]2[C:7]3[CH:13]=[C:12]([CH3:14])[N:11]([CH2:15][C:16]4[CH:21]=[CH:20][C:19]([CH2:22]O)=[CH:18][CH:17]=4)[C:8]=3[CH:9]=[CH:10][C:5]2=[N:4][N:3]=1.Cl.[NH:25]1[CH2:28][CH:27]([OH:29])[CH2:26]1.C(N(C(C)C)CC)(C)C>>[CH3:1][C:2]1[N:6]2[C:7]3[CH:13]=[C:12]([CH3:14])[N:11]([CH2:15][C:16]4[CH:17]=[CH:18][C:19]([CH2:22][N:25]5[CH2:28][CH:27]([OH:29])[CH2:26]5)=[CH:20][CH:21]=4)[C:8]=3[CH:9]=[CH:10][C:5]2=[N:4][N:3]=1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 27592903-Hydroxyazetidine hydrochlorideHCID 118159705HCID 118159705, compound

Product 1

HCID 118159814HCID 118159814, compound

Procedure

The title compound was prepared according to the procedures of Example 45, using the alcohol of Example 49 as starting material and using azetidin-3-ol hydrochloride (21 mg, 0.20 mmol, Oakwood) and diisopropylethylamine (34 μL, 0.20 mmol) in the displacement, which was performed overnight (10.3 mg, 58%).

Sources & evidence

ORD record
ord-e34cf2b17ec849bd9bfe965ee4cffd4f
Source dataset
uspto-grants-2016_04
Patent number
US09309246B2

Reaction notes

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