反应详情

温度

110 °C

1-Benzyl-5-chloro-2-[1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]-1H-pyrrolo[3,2-b]pyridine (0.106 g, 0.270 mmol, from Step 1), di-tert-butyl hydrazine-1,2-dicarboxylate (0.069 g, 0.30 mmol) and Cs2CO3 (0.088 g, 0.27 mmol) were combined in toluene (2.4 mL) and dicyclohexyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine-(2′-aminobiphenyl-2-yl)(chloro)palladium (1:1) (0.021 g, 0.027 mmol) was added. The mixture was degassed by a stream of nitrogen through the solution for 10 minutes. The reaction was heated to 110° C. for 1.5 hours, at which time additional reagents and catalyst were added (same of each as the initial quantities) and the mixture was degassed again and was heated in the microwave to 140° C. for 10 minutes. The reaction mixture was partitioned between EtOAc and water, extracted three times and the combined extracts were dried over sodium sulfate, filtered, and concentrated. The resulting product was purified via preparative HPLC-MS (C18 eluting with a gradient of MeCN and H2O containing 0.15% NH4OH). Yield (71 mg, 44%).

1. customThe mixture was degassed by a stream of nitrogen through the solution for 10 minutes
2. additionwere added (same of each as the initial quantities) and the mixture
3. customwas degassed again
4. temperaturewas heated in the microwave to 140° C. for 10 minutes
5. customThe reaction mixture was partitioned between EtOAc and water
6. extractionextracted three times
7. dry with materialthe combined extracts were dried over sodium sulfate
8. filtrationfiltered
9. concentrationconcentrated
10. customThe resulting product was purified via preparative HPLC-MS (C18
11. washeluting with a gradient of MeCN and H2O containing 0.15% NH4OH)
12. customYield (71 mg, 44%)