Trifluoroacetic acid → HCID 178511296, compound

HRID 628357Notes

Reaction equation

HRID 628357 reaction equation
[C:1]([C@H:3]1[CH2:6][C@H:5]([NH:7]C(=O)OC(C)(C)C)[CH2:4]1)#[N:2].[C:15]([OH:21])([C:17]([F:20])([F:19])[F:18])=[O:16]>C(Cl)Cl>[F:18][C:17]([F:20])([F:19])[C:15]([OH:21])=[O:16].[NH2:7][C@H:5]1[CH2:6][C@H:3]([C:1]#[N:2])[CH2:4]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178454087HCID 178454087, compound

Product 1

HCID 178511296HCID 178511296, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl (trans-3-cyanocyclobutyl)carbamate (0.061 g, 0.31 mmol) was stirred with TFA (2 mL) in DCM (4 mL) for 1 hour. The solvents were removed in vacuo and the residue was reconstituted in DCM and subjected to rotary evaporation an additional 2 times to rid of excess TFA in the product, which was used without further purification in Step 5.

Workup

  1. customThe solvents were removed in vacuo
  2. customsubjected to rotary evaporation an additional 2 times
  3. customwas used without further purification in Step 5

Sources & evidence

ORD record
ord-f07d0eb518f742c2895ae1c18e1f6d79
Source dataset
uspto-grants-2016_04
Patent number
US09309246B2

Reaction notes

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