反应详情

Carbethoxyethylidene triphenylphosphorane (1.02 g, 2.81 mmol) was dissolved in anhydrous THF (25 mL), and 4-benzyloxy-benzaldehyde (0.5 g, 2.36 mmol)/THF (10 mL) solution was added dropwise thereto at −78° C. The mixture was heated slowly to room temperature and then stirred for 12 hours. After the termination of the reaction, the reactant was concentrated under reduced pressure. The residue was added with water and then extracted with EtOAc. The organic layer was dried with MgSO4 and purified by column chromatography (eluent, EtOAc/Hex=1/9) to obtain the title compound (0.68 g, 97.4%).

1. customat −78° C
2. customAfter the termination of the reaction
3. concentrationthe reactant was concentrated under reduced pressure
4. additionThe residue was added with water
5. extractionextracted with EtOAc
6. dry with materialThe organic layer was dried with MgSO4
7. custompurified by column chromatography (eluent, EtOAc/Hex=1/9)